Lussier started working in film as an assistant editor on the television series The Hitchhiker, which was soon followed with stints on 21 Jump Street and MacGyver, where he was promoted to full-time editor.
His editing work has earned him Gemini award nominations for the telefilms Heads and Adrift.
In the early 90s, Lussier began a long association with director Wes Craven. The two worked together on the television series Nightmare Café. Lussier went on to edit Craven's films such as New Nightmare, Vampire in Brooklyn, and the Scream trilogy.
When not working with Craven, Lussier built up credits of his own including editing the Doctor Who series in 1996, and films like D3: The Mighty Ducks, Mimic and Music of the Heart.
For the start of the new millennium, Lussier decided to take another role behind the camera as director. He completed The Prophecy III: The Ascent starring Christopher Walken, before diving into his next project Dracula 2000, starring Gerald Butler and Christopher Plummer. White Noise 2: the Light didn't receive a theatrical release in North America, but his next film, My Bloody Valentine (2009) was his most successful at the box office to date. He was next signed to direct Drive Angry 3D, with a $50 million budget, starring Nicolas Cage.